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2006 January 26

Under pathological stimulation, overactivation of microglia leads to the release of large amounts of pro-inflammatory factors, ROS, and nitric oxide (NO), triggering uncontrolled inflammatory responses that ultimately result in neuronal damage and sustained neuroinflammation [68]

rhIGF-1/rhIGFBP-3 in preterm infants: a phase 2 randomized controlled trial

Combining them would negate the primary advantage of the peptide approach

Ferroptosis also plays a significant role in comorbidity