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Among the known signal transduction pathways related to apoptosis is the activation of UPR pathways during ER stress, which leads to the activation of caspase-12, CHOP (C/EBP homologous protein) and c-Jun NH-terminal kinase (JNK) proteins (93,94)

These osteoprotective effects were accompanied by metabolic improvements, including dose-dependent decreases in blood glucose levels and RANKL concentrations, and increases in calcium (Ca) and phosphate (P) concentrations (71)

Cells were then infected separately with either MS_ Rv0801 or MS_pAL at a MOI of 10 for 24 hours

OAT10 ( SLC22A13 ) is a urate and high-affinity nicotinate transporter expressed in brush border membrane vesicles from proximal tubules and, interestingly, also in cortical collecting ducts in rats (60)

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