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Use adaptive dosing and staging matched to disease phase and compartment: for example, early ischemiareperfusion may benefit from acute, time-boxed control of mitochondrial bursts and labile iron to limit Fenton chemistry, while chronic vascular or organ remodeling calls for rebalancing NOX activity and ER stress together with lifestyle re-entrainment (exercise, nutrition, sleep, exposure control) to reset redox tone without erasing physiological H 2 O 2 signalling (Poznyak et al

doi: 10.1080/19390211.2019.1699223, 156

Am J Physiol Cell Physiol 292:C157C163 Fecher C, Trovo L, Muller SA, Snaidero N, Wettmarshausen J, Heink S, Ortiz O, Wagner I, Kuhn R, Hartmann J, Karl RM, Konnerth A, Korn T, Wurst W, Merkler D, Lichtenthaler SF, Perocchi F, Misgeld T (2019) Cell-type-specific profiling of brain mitochondria reveals functional and molecular diversity

Research in rats have shown that supplementation with zinc gluconate or zinc citrate resulted in a significant increase in zinc concentrations in the prostate, while zinc sulfate had no effect