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Inhibiting any of the aforementioned pathways might thus theoretically accelerate ferroptosis in HCC cells
It is an orphan drug approved by the FDA and can be used in protecting the heart from the cardiotoxic effects of anthracyclines, such as doxorubicin
A subset of genes, including bile acid synthesis gene Cyp8b1 , responded in an opposite direction during fasting and after glucose feeding
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Moreover, ferrous iron is transported from the endosome into the cytoplasm via divalent metal transporter 1 (DMT1), entering the metabolically labile iron pool (LIP)
