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Interestingly, a realworld observational study comparing semaglutide and tirzepatide found that the risks of GI side effects, including gastroparesis, gastroenteritis, bowel obstruction, cholecystitis, cholelithiasis, and pancreatitis, were similar between the two medications [34]
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Gut health patients often notice improvement within 7 to 14 days
Additionally, dietary changes often accompany diabetes management and weight loss efforts, which may inadvertently increase intake of histamine-rich foods or trigger pre-existing sensitivities

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