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232,233 In addition to the inactivating mutation of Wnt/-catenin pathway components, abnormal secretion of Wnt ligands in many tumours can also lead to overactivation of the Wnt/-catenin pathway (DKK1, Wnt3a, and Wnt5a)

165 LRP6 is downregulated in the AD brain, and deficiency in LRP6-mediated Wnt/-catenin signalling contributes to synaptic dysfunction and amyloid pathology in AD

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