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432 A 2021 systematic review and meta-analysis that included 22 observational studies with a total of 440,281 elderly participants with atrial fibrillation taking rivaroxaban, dabigatran, apixaban, or edoxaban found these medications were associated with similar reductions in risks of stroke and other embolic events, but rivaroxaban was associated with more bleeding events than apixaban or edoxaban

To detect any contamination by genomic DNA, the primers were designed to span intron-exon boundaries

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430 Another study examined the safety of switching from warfarin to a DOAC in frail elderly patients with atrial fibrillation

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