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While the primary mechanisms of CPZ toxicity are poorly understood, in vitro studies report CPZ toxicity to be limited to primary oligodendrocytes (Bnardais et al., 2013) while others suggest the requirement of pro-inflammatory cytokines (Pasquini et al., 2007)

doi: 10.1097/00004872-200401000-00021

Contribution of cyp1a2 in the hepatic metabolism of melatonin: Studies with isolated microsomal preparations and liver slices

Instead, they proliferate in lymphoid organs, where interactions with extracellular matrix, stromal cells, and/or other lymphocytes may play a role

Microbial production of vitamin B(12): a review and future perspectives