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Dihexa/fosgonimeton is the latest example of this valley of death between preclinical promise and clinical reality

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Regulation of intracellular glutathione

Sepsis-associated encephalopathy and blood-brain barrier dysfunction

The enhanced bactericidal effect of rGO-WiC was attributed to sharp edges, oxygen-functional groups, ROS generation, and possibly ferrocene-derived metallic impurities contributing to oxidative stress and membrane rupture

As it turns out, the connection is significant