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Blood samples were collected from dogs administered multiple doses at corresponding time points before the first dosing (0 h), within 6 h after dosing, before the last three doses, and at corresponding time points after the last dosing

doi: 10.1159/000318113

Hong S et al

This should occur given rectus femoris muscle biarticular muscle origin (i.e., above the hip joint and below the knee joint line), with both hip flexor and knee extensor function consistently affected

Why is it so important not to shake the vial after adding the water