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l-Carnitine in Neurodegenerative Diseases Mitochondrial dysfunction appears to be an important early underlying factor in the development of neurodegenerative diseases such as Alzheimers, Parkinsons, Huntingtons, and dementia

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However, these data are difficult to unambiguously interpret for technical reasons

Saxton RA, Sabatini DM

In addition mutation in HADHA can lead to isolated LCHAD deficiency and mutations in the HADHB gene to isolated LCKAT deficiency