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Through integrated analysis of single-cell RNA sequencing data, clinical specimens, and in vivo and in vitro experiments, we identified FAP+ CAFs as the predominant stromal population associated with poor clinical outcomes and immunosuppressive features

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It was evidenced in the current study that seed extract and L-dopa have the potential to ameliorate neuronal apoptosis by regulating the PI3K/Akt signalling pathway and its consequence on the molecular targets forkhead box transcription factor and glycogen synthase kinase 3, in addition to deflecting neurodegenerative diseases like Parkinsons caused by induced neurotoxicity

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