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When the early signal also happened to favor a lower dose over a higher one an inverted dose-response that is a classic warning sign of noise rather than a true pharmacological effect the case for genuine efficacy was already fragile before the pivotal trial delivered its verdict

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Downstream observations in models include transcriptional changes consistent with enhanced mitochondrial function and lipid utilization

Daily supplementation with fresh Angelica keiskei juice alleviates high-fat diet-induced obesity in mice by modulating gut microbiota composition (in Eng)