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BMAL1 regulation of microglia-mediated neuroinflammation in MPTP-induced Parkinsons disease mouse model

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[DOI] [PMC free article] [PubMed] [Google Scholar] 71.Ellulu M.S., Patimah I., Khazaai H., Rahmat A., Abed Y

While Huntingtons disease is widely considered to be due to a gain-of-function toxic effect, it has been demonstrated through selective deletion of Htt in striatal projection neurons of mice that these neurons require Htt for motor regulation, synaptic development, cell health, and survival during aging ( Free copper enhances the aggregational toxicity of Htt (Lobato et al., 2024)

Following GSH treatment, the levels of POD in the GSH96 group were significantly higher than those in the GSH48 group and were also significantly higher than those in any of the other treatment groups