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doi: 10.1016/j.pharmthera.2021.107996

T., Tamai, K

Warne CD, Zaloumis SG, Bertalli NA, et al

In the current study, we directly compared the performance of adult and aged xCT +/+ and xCT / mice in the Barnes maze task, using a protocol with longer inter-trial intervals to avoid bias due to differences in spatial working memory, to specifically assess the effect of xCT deletion on age-related changes in hippocampus-dependent reference memory

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Bilirubin likely activates AHR but this effect and the concentration (K d or EC 50 ) at which it occurs is yet to be validated in KO animals [51] or by CRISPR KO technology in cell lines