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Blood, J Am Soc Hematol

This dual-action mechanism intercepts potential damage at multiple levels and supports overall cellular homeostasis [68]

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S6K and 4EBP1 had persistent phosphorylation in the RP/MRD cells without MTOR mutations (HCV29RP, 97-1RP), and yet the rapamycin-FKBP12 complex still bound to MTOR