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For a long time, it was the only option

The intermittent shift between hyperoxic-normoxic exposure, in addition to being safe and feasible, has been shown to enhance erythropoietin production and raise hemoglobin levels with numerous different potential applications in many fields of therapy as a new strategy for surgical preconditioning aimed at frail patients and prevention of postoperative anemia

GGCT promotes colorectal cancer migration and invasion via epithelial-mesenchymal transition

On the other hand, mice lacking IGFBP3, -4, or -5 developed normally and only IGFBP4 deficient mice showed a modest (8590% compared to wild type) growth retardation [108], suggesting that other IGFBPs compensate for the loss of IGFBP5
Farooqui AA, Farooqui T, Panza F, Frisardi V
