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We discuss the use of glucagon-like peptide-1 (GLP-1) analogues as monotherapy and unimolecular dual or triple agonists that exploit the GLP-1 receptor and/or the gastric inhibitory peptide (GIP) receptor and/or the glucagon receptor

Glucagon-like peptide-1 increases heart rate by a direct action on the sinus node GLP-1 has direct chronotropic effects on the heart mediated by GLP-1 receptors in pacemaker cells of the sinus node, inducing changes in action potential morphology

Learn why the 4-week titration is vital for safety and how to manage early side effects.

In this review, we summarize the state-of-the-art evidence regarding the epidemiology and pathophysiology of diabetic HFpEF, and the landscape of the novel antidiabetic drugs in the treatment of diabetic HFpEF, as well as discuss the relevant mechanisms, aiming to broaden the understanding of diabetic HFpEF and gain new insight into the treatment of this disease

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At the same time, transformation stories online often underplay the less glamorous realities: Muscle loss alongside fat loss Nutritional compromise from severely reduced intake Hair loss, fatigue, nausea, and GI adverse effects Weight regain after discontinuation Psychological pressure surrounding body image Unsupervised or socially influenced use Perhaps the most important point: these medications were never meant to replace lifestyle modification