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DRM is usually caused by the joint action of an underlying disease []

In humans, it is found mainly in tissues such as the liver and is the dominant form in many non-human animals

For many chronic inflammatory conditions, the combination of Curcumin (Turmeric) together with Quercetin is a powerfulone

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Although mechanisms describing the interaction between the key pathway constituents Nrf2, Keap1 and p62 are widely reviewed and discussed in literature, quantitative dynamic models bringing together these mechanisms with time-resolved data are limited