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Ultimately, tissues are more vulnerable to OS and, consequently, to diabetic complications, especially vascular problems, which are the main cause of comorbidity and mortality in DM2

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Interventions for the management of dysregulated iron homeostasis Most anaemias resulting from absolute iron deficiency can be effectively managed through iron supplementation therapy [96, 97]

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Annu Rev Pharmacol Toxicol 47:14383, PMID: 17029566 Kaludercic N, Takimoto E, Nagayama T, Feng N, Lai EW, Bedja D, Chen K, Gabrielson KL, Blakely RD, Shih JC, Pacak K, Kass DA, Di Lisa F, Paolocci N (2010) Monoamine oxidase A-mediated enhanced catabolism of norepinephrine contributes to adverse remodeling and pump failure in hearts with pressure overload