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doi: 10.1038/s41392-023-01569-3 Summary Keywords arginine metabolism, glutamine metabolism, immunometabolism, metabolic reprogramming, therapeutic targeting, tryptophan catabolism Citation Yin Y, Yan C, Pei X, Rao J, Wu L, Xue Y, Sun H and Sheng Y (2026) Amino acid metabolism modulates macrophage polarization: implications for autoimmune-related diseases

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A decrease in plasma/bloodstream glutamine levels results of either insufficient glutamine production in skeletal muscle or excessive consumption by utilizing-cells or both (Figure 2)

In summary, alveolar epithelial cells, alveolar macrophages, and vascular endothelial cells within the lung express essential iron-handling proteins such as TfR, ferritin, FPN, and their regulatory transcription factors

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