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[DOI] [PMC free article] [PubMed] [Google Scholar] 212.Remigante A., Spinelli S., Straface E., Gambardella L., Caruso D., Falliti G., Dossena S., Marino A., Morabito R

This PTM impedes the activation of the NF-B signaling pathway by preventing the binding of glycogen synthase kinase 3 beta (Gsk3) [35]

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doi: 10.1534/genetics.110.125567

It can be triggered by photo exposure, pregnancy, hormonal changes and medications, but its pathogenesis is not completely understood, reflected in the frequent recurrence after treatment.1,2 Oxidative stress, caused by external factors such as exposure to solar radiation, sleep disorders, pollution, skin inflammation and emotional stress, can induce and perpetuate melanogenesis regardless of ultraviolet irradiation

But you must use caution when using this strategy, making sure you select a high-quality product and follow a programme that takes into account your food, lifestyle, and dose