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Previous studies have documented the ability of NFATc2 to efficiently stimulate microglia in neurodegenerative disorders, and its expression is increased in individuals with PD (Quan et al., 2024)

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MPs might also act to sequester anticancer drugs by expressing the drug efflux transporter P-gp on their surfaces, as an active mechanism, and through the diffusion of chemotherapeutic drugs, such as DOX, anthracyclines, and daunorubicin across the MP membrane, as a passive mechanism (120, 373)

Supplementary Figure 9 Correlation across different vendors Most clinical laboratory measurements were assayed by only one of the lab vendors (Quest or Genova) but certain measurements were measured by both due to overlaps in the standard analysis panels

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Omavaloxolone engages the cells endogenous antioxidant response, and while it can attenuate the progression of Friedreichs ataxia, it is not curative