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53 Furthermore, observational and clinical studies indicate postmenopausal hormone replacement therapy is associated with lower liver enzyme levels, protection against metabolic dysfunction, and lower risk of NAFLD

315 Andrographolide shows an inhibitory effect on the proliferation of MCF-7 cells through ER-mediated transcription and undergoes crosstalk with PI3K/Akt/mTOR signaling in a concentration-dependent manner, and the effects is comparable to that of the anticancer drug fuvinsetron, indicating its potential role as a possible anti-estrogenic agent in the treatment of breast cancer

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if the outer annulus fibrosus subsequently ruptures, the nucleus pulposus completely extrudes (non-contained herniation), potentially protruding into the spinal canal or lateral recess, compressing the cauda equina and nerve roots, causing pain or motor dysfunction (Figure 1)

References Jones, A

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