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The full extent of the age-associated mitochondrial impairment only became clear when the molecular data were examined

Increased cross-gender identification independent of gender role behavior in girls with congenital adrenal hyperplasia: Results from a standardized assessment of 4-to 11-year-old children

This NAD+ elevation activates sirtuins (particularly SIRT1), enhances mitochondrial function, and preserves methylation capacity by reducing S-adenosylmethionine (SAM) consumption

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Judging from the fact that -GCS and GS proteins do not associate and that their gene expression is controlled differently [141], it is reasonable to consider that in certain situations, -GCS acts dominantly compared with GS and produces -glutamyl peptides other than glutathione