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F., Ding, J

Insulin-like growth factor-I restores the reduced somatostatinergic tone controlling growth hormone secretion in cirrhotic rats

Antiapoptotic effects of EEBC in SCO-mediated memory deficit mice Accumulating evidence demonstrates that the cholinergic system is closely associated with the apoptotic pathway in neuronal cell death 28,29

The phase II trial investigating the addition of the anti-HGF antibody rilotumumab to ECX (epirubicin, cisplatin and capecitabine) chemotherapy in gastric adenocarcinoma demonstrated a modest improvement in progression-free survival (PFS, 5.7 vs 4.2 months) and objective response rate (ORR, 39% vs 21%) [86] compared to placebo plus ECX

A-mediated oxidative stress can cause metabolic alterations in the brain, such as lipid peroxidation and ROS production (50) leading to synaptic loss and cognitive dysfunction (51)

Inspired by this observation, we chose to investigate the presence of small urinary peptides associated with IC/BPS