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IC 50 for membrane potential response was estimated to be less than 5 M ADP for all groups

Li J, You S, Zhang S, Hu Q, Wang F, Chi X, et al

Radical Scavenging by Thiols and the Fate of Thiyl Radicals

While most of the canonical IGF-IR signaling processes are conducted in the cytosol, IGF-IR may translocate to the nuclei and then regulate gene transcription, which represents a non-canonical function of IGF-IR

Increased amounts of reactive oxygen species (ROS) in cancer cells may facilitate tumour development, genetic instability, and resistance to programmed cell death (apoptosis) [11, 94, 95]