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This is a critical, non-negotiable element of healing
But sadly that production decreases with age, which arguably is when we need it most as stores are easily depleted by oxidative stress, inflammation and dealing with toxins

Morrison, Dermal matrices and bioengineered skin substitutes: a critical review of current options

Another set of signaling pathways involved in oxidative stress response includes ferroptotic, apoptotic, FoxO, and ErbB pathways (Liang et al., 2017

This is due to the general belief that bulk porosity is negatively correlated with stiffness
Administration of NAC, although could improve antioxidant parameters in the intervention group before and after receiving NAC, however, the results were not statistically significant except for TOS
