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Increase fiber gradually across the first 4 to 6 weeks while you keep water intake steady, and ask your clinician or pharmacist before starting fiber supplements, laxatives, magnesium, stool softeners, or other over-the-counter options

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Preclinical findings show remarkable consistency: GLP-1R agonists reduce voluntary substance intake, block drug-induced dopaminergic activation, inhibit conditioned reward learning, and attenuate relapse-like behaviors

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These changes suggest that GLP-1R signaling exerts its anti-craving effects, at least in part, by altering synaptic plasticity in addiction-related circuits