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Preclinical studies indicate that NNMT knockdown or inhibition can protect against diet-induced weight gain and improve metabolic parameters without reducing food intake [5] [6]
Most of the current evidence comes from small studies
High-Dose Spermidine Supplementation Does Not Increase Spermidine Levels in Blood Plasma and Saliva of Healthy Adults: A Randomized Placebo-Controlled Pharmacokinetic and Metabolomic Study
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This result is broadly consistent with pre-clinical models of psychosis that show that environmental stress affects the GABAergic system in humans (Zhang et al
