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Description
BMIbody mass index, yyears, kg/m 2 kilograms divided by height in meters squared, DMdiabetes mellitus, RGCsretained gastric contents

JCI Insight (2023)

10.1038/nchembio.209 28 DeaconC
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Once daily injectable liraglutide (marketed as Victoza for T2DM and Saxenda for obesity) and once weekly injectable semaglutide (marketed as Ozempic for T2DM and Wegovy for obesity) are two additional GLP-1 analogues, sharing 97% and 94% amino acid homology to GLP-1, respectively [ Figure 2 , Table 1 ]

The addition of GIP receptor agonism in tirzepatide does not appear to significantly amplify heart rate effects compared to GLP-1-only drugs like semaglutide
