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HSP-90 facilitates HBV capsid assembly, which is an important step for the packing of viral particles [116]

In accordance with the role of the fumarate accumulation with cytotoxicity and oncogenic capacity, it was demonstrated that cells exposed to high levels of fumarate and succinate lead to extensive DNA fragmentation and altering the global DNA methylation patterns via DNA hypermethylation in human hepatocellular carcinoma (195)

The use of viral vectors as a methodology was initially attempted as early as the 70s (e.g., (Jaenisch 1976)), prior to the successes of pronuclear microinjection

Although the mechanisms by which these reagents modulate GPx1 expression are not clear, it has been shown that GPx1 can be upregulated by activation of the peroxisome proliferator-activated receptor--coactivator-1a (PGC1) pathway, possibly via the subsequent activation of Nrf2 [161]