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These cells frequently efflux cholesterol via two primary mechanisms: firstly, by upregulating cholesterol 24S-hydroxylase (CYP46A1), which facilitates the conversion of cholesterol into 24(S)-hydroxycholesterol (24-OHC), a compound capable of freely crossing the bloodbrain barrier [317]

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Nutrients 11:1606 Crowe S, Barot J, Caldow S, dAspromonte J, DellOrso J, Di Clemente A, Hanson K, Kellett M, Makhlota S, McIvor B, McKenzie L, Norman R, Thiru A, Twyerould M, Sapega S (2011) The effect of caffeine and stress on auditory hallucinations in a non-clinical sample