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MerR Family Zn II Sensor The canonical Zn II efflux regulator (Figure 6) Ec ZntR is characterized by a conserved CCx 3 Hx 4 C motif in the MBL and a Cys in the N-terminal region of the 5 helix, which collectively create a binuclear Zn II cluster in which the two Zn II ions adopt approximately tetrahedral coordination geometries (Figure 11D)