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Although present observations have unveiled the practical meaning of promoted FAO via LCA in obesity-dependent AF, and indicating the leading role of FAO in AF pathogenesis, this study failed to directly assess the efficiency of FAs uptake or FAO in vivo , and whether the LCA-conferred anti-AF effects is mediated by AMPK also needs confirmation in vivo

Pharmacol Rev 70:549620 Galley G, Stalder H, Goergler A, Hoener MC, Norcross RD (2012) Optimisation of imidazole compounds as selective TAAR1 agonists: discovery of RO5073012