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R., DeGheselle, O., Smeets, K., Van Kerkhove, E., & Cuypers, A

Curcumin inhibited the nuclear translocation of -catenin and decresed the expression of its target genes CyclinD1, c-Myc and Axin2 in CRC cells and AOM/DSS model mice, which demonstreted Curcumin play a role in targeting the Wnt/-catenin signaling pathway ( Magnolia officinalis Rehd
We also confirmed that knockdown of either PERK or HSP90 consistently accelerated the MZ1-induced degradation of endogenous BRD4 (Fig

Targeting autophagy using small-molecule compounds to improve potential therapy of parkinson's disease
Knockout of insulin-like growth factor-1 receptor impairs distal lung morphogenesis

10.1038/s41422-018-0056-0 Cell Res
