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This approach is exemplified by Dichloroacetate, an inhibitor of pyruvate dehydrogenase kinase that diverts pyruvate away from lactate conversion and into mitochondria, and by Lonidamine, which suppresses glycolysis at its origin by inhibiting mitochondrially-bound hexokinase

Des Weiteren weisen die Daten aus anderen Studien darauf hin, dass, verglichen mit der Monotherapie, die Anwendung von Antiepileptika in einer Kombinationstherapie mit einem erhhten Risiko fr teratogene Effekte verbunden ist

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Understanding the in-vivo relevance of S -nitrosothiols in insulin action

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Elongated ketoacid can be again aminated by a BCATs to yield the side-chain elongated Met (homoMet), which is either channeled into GSL biosynthesis or can proceed through another round of chain elongations to yield dihomoMet, trihomoMet, etc