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The domain-swapped dimer, previously observed in crystal structures, is the repeating unit, and helical formation is driven by inter-dimeric RD interactions, i.e., between the RDs of neighbouring subunits of the filament

Akt activation phosphorylates and inhibits FOXO transcription factors, reducing protein catabolism

Phenytoin may be affected by drug-drug interactions due to competition for protein binding

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Mulberry fruit prevents diabetes and diabetic dementia by regulation of blood glucose through upregulation of antioxidative activities and creb/bdnf pathway in alloxan-induced diabetic mice