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The following is a summary of documented tissue systems from peer-reviewed literature: This cross-tissue activity profile is directly attributable to the fact that its primary mechanisms VEGFR2-driven angiogenesis and NO system modulation are not tissue-specific

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Additionally, patients with Multiple Endocrine Neoplasia syndrome type 2 should not receive tirzepatide due to the theoretical increased risk of medullary thyroid carcinoma associated with this genetic condition