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Anti-CD122 therapy, either systemically or locally, decreases TRM-induced IFN- production and results in long-term repigmentation

4- Rosebush MS, Briody AN, Cordell KG

Key points: Condition treated: Erythropoietic protoporphyria (EPP) Mechanism: Stimulates melanin to reduce light sensitivity Result: Fewer painful reactions and improved quality of life Research also explores its use in polymorphous light eruption (PLE) and other photosensitive disorders

Thus, the use of large punches is not recommended

This latter effect results in a reduced capacity for removal of cholesterol from lipid-laden macrophages (foam cells) leaving the foam cells in a more pro-inflammatory state

doi: 10.1038/s41598-020-80122-6