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34 A recent analysis from the Cochrane Database of Systematic Reviews concludes that NAC likely has a modest beneficial effect on respiratory exacerbations and quality of life in patients with COPD, but that the effect tends be smaller in recent larger studies

With decreasing kidney function, levels of serum holoTC rise to ensure sufficient holoTC is delivered into cells

Amendments are therefore proposed to ensure the clinical trial exemptions cover when products are also actually used in a clinical trial

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