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doi: 10.3390/molecules28010210 [DOI] [PMC free article] [PubMed] [Google Scholar] 44.Lakhan SE, Vieira KF

When comparing first-in-human trials vs Phase 1 clinical studies you will see a difference in design

320 In GBM, TGF- critically contributes to immune evasion by suppressing the cytotoxic activity of CTLs and NK cells, thereby hindering the host immune response against tumor cells
Compared with regular -oryzanol, nano -oryzanol markedly ameliorated lipid and blood glucose metabolism in obese diabetic ob/ob mice with an unexpected amount (about 1000-fold lower dose)

Issa JP, Castoro R, Ravandi-Kashani F, Faderl S, Huang X, Estey E, Borthakur G , Morris G, Garcia-Manero G, Kantarjian H

GC91380 N6F11 N6F11 is a novel, selective and potent inducer of iron death with anticancer and antitumour activity that promotes GPX4 degradation by binding to TRIM25 in cancer cells
