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In particular, adenosine receptors (ADOR) A1 and A2B were expressed in both PD plaque-derived cells and tunica-derived cells ( Additionally, it has been proposed that ROCK inhibitor could attenuate TGF-1 signaling and myofibroblast transformation ( Most noteworthy, there is an increasing number of emerging therapies for several fibrotic disorders, e.g., pulmonary, liver, and kidney fibrosis ( Stem Cell Therapy of PD Available data has shown that adipose-derived stem cells (ADSCs) could increase the production of growth factors, modulate the ECM, replace the injurious tissue, and diminish inflammation ( smooth muscle actin (SMA) of myofibroblasts in tunica albuginea, and inhibit the Rho/RhoA and SMAD signaling pathway ( The effects of intralesional human ADSCs on animal model of PD in acute phase was first assessed in 2013 ( Because of these potential limitations, a single-center, phase I, non-randomized study was conducted to evaluate the efficacy and safety of SC therapy for patients with PD using placental matrixderived mesenchymal SC (PM-MSCs) ( In a word, despite the lack of qualitative trials with larger samples and long-term follow-ups, SC therapy has revealed the advantage of balancing pro-fibrotic and anti-fibrotic elements

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