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There is no single correct amount more water simply spreads the same 20 mg of peptide across a larger volume, which makes small doses easier to measure accurately

We propose a new perspective: LPD may not simply be a consequence of DOR, but may itself actively contribute to the pathogenesis and progression of DOR through multiple pathways

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Acknowledgements The authors sincerely thank all participants and their families/caregivers for their valuable contribution to this research

All infections were performed using a standardized inoculum of 1 10 7 colony-forming units (CFU) suspended in phosphate-buffered saline (PBS) and administered via the intranasal route using 50 l/nostril

Both of these peptides are small, both are reasonably soluble in BAC water, and both have well-behaved chemistry on a clean reconstitution