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A study in 2022 used this model to screen out a novel ALK5 inhibitor, TP-008, which reduced collagen deposition in mouse pulmonary fibrosis models by 70% (Luttens et al., 2025)

However, the abovementioned studies hold a few limitations

However, when used at high pharmacological levelsfar exceeding the bodys natural productionTRT may shift from therapeutic to harmful

The chemically chopped up version of the big protein molecule, collagen

aberrant regulatory patterns of tumor cells within this network can directly lead to drug resistance [16]