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However, due to uncertainties and lack of evidence on multiple aspects related to the diagnosis and treatment of vitamin B12 deficiency, widely accepted guidelines are still needed due to between-country differences in medical practices, healthcare systems, and generally limited resources

Injectable B12 is often preferred because it bypasses the digestive system and delivers the vitamin directly into the body

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Per ASCO guidelines, duloxetine is the only agent with moderate evidence for CIPN pain relief

(More information) Both depression and osteoporosis have been linked to diminished vitamin B 12 status and high homocysteine levels

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