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In a recent study, the one-year discontinuation rate among newly prescribed patients was notably high, ranging from 91% for tricyclic antidepressants (TCA) to 73.7% for selective serotonin reuptake inhibitor/serotoninnorepinephrine reuptake inhibitor (SSRI/SNRI) antidepressants

For example, one study found that individuals in the highest quintile of serum vitamin D had significantly lower odds of early AMD (OR = 0.64) [103]

The need for chronic injection as a means of therapy always runs into the problem of patient compliance

Lipopolysaccharide (LPS) was administered to induce depression and anxiety-like symptoms such as a decreased grooming tendency, diminished locomotive activity, and increased immobility period

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