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This modification renders the peptide resistant to enzymatic degradation, significantly extending its half-life and potency in vivo compared to standard L-peptides

Obviously, the smaller size NPs showed higher efficiency in infiltrating and crossing the BBB

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In addition, many of the patients were receiving MTX in combination with other cytotoxic agents, which caused difficulties in attributing all adverse events to MTX therapy

Brain-derived neurotrophic factor in astrocytes, oligodendrocytes, and microglia/macrophages after spinal cord injury

Zhao YJ, Zhu WJ, Wang XW, Zhang LH, Lee HC