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Activated microglia and astrocytes release proinflammatory cytokines including tumor necrosis factor-alpha (TNF- ), interleukin-6 (IL-6), and interleukin-1 (IL-1), creating a hostile neuroimmune milieu ( In PD brains, persistent glial activation is associated with regions of dopaminergic degeneration, indicating a spatial correlation ( Epigenetic regulation also influences proteostasis in PD

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In addition, biological processes that depend on O 2 and nitrogen have gained greater importance because their end-products are usually found in states of high metabolic requirements, such as pathological processes or external environmental interactions [2]

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The presence of pyrrolizidine alkaloids in BP can create severe conditions of lung cancer and hepatotoxicity, which are strongly related to the botanical origin of BP