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Sublingual administration achieves 55% penetration after 10 minutes and approximately 70% after 30 minutes through oral epithelium

Impairment of autophagic degradation and mitochondrial dysfunction are also significant factors, as evidenced by accumulation of autophagosomes and suppression of mitochondrial oxygen consumption rates in DOX-treated hearts [14]

Drug Metab Pharmacokinet 24, 226234

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